{"id":1587,"date":"2022-08-15T04:38:48","date_gmt":"2022-08-15T04:38:48","guid":{"rendered":"https:\/\/hencosvn.com\/?p=1587"},"modified":"2022-08-15T04:38:48","modified_gmt":"2022-08-15T04:38:48","slug":"tim-hieu-ve-nam-da-qua-qua-trinh-tong-hop-melanin-va-cac-hoat-chat-uc-che","status":"publish","type":"post","link":"https:\/\/hencosvn.com\/?p=1587","title":{"rendered":"T\u00ecm hi\u1ec1u v\u1ec1 n\u00e1m da qua qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p melanin v\u00e0 c\u00e1c ho\u1ea1t ch\u1ea5t \u1ee9c ch\u1ebf"},"content":{"rendered":"<h2><strong>N\u00e1m da l\u00e0 g\u00ec?<\/strong><\/h2>\n<p><strong>N\u00e1m da l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n s\u1eafc t\u1ed1 x\u1ea3y ra khi qu\u00e1 tr\u00ecnh r\u1ed1i lo\u1ea1n melanin<\/strong> t\u0103ng ti\u1ebft, l\u01b0\u1ee3ng melanin \u0111\u01b0\u1ee3c s\u1ea3n sinh nhi\u1ec1u v\u00e0 b\u1ecb \u0111\u1ea9y s\u00e2u v\u00e0o b\u00ean trong l\u1edbp th\u01b0\u1ee3ng b\u00ec.<\/p>\n<p>Hi\u1ec3u m\u1ed9t c\u00e1ch \u0111\u01a1n gi\u1ea3n h\u01a1n th\u00ec n\u00e1m da l\u00e0 t\u00ecnh tr\u1ea1ng da xu\u1ea5t hi\u1ec7n nh\u1eefng \u0111\u00e1m m\u00e0u n\u00e2u ho\u1eb7c m\u00e0u x\u00e1m n\u00e2u tr\u00ean da nh\u1ea5t l\u00e0 nh\u1eefng v\u1ecb tr\u00ed nh\u01b0 m\u1eb7t, tr\u00e1n, c\u1eb1m, s\u1ed1ng m\u0169i, hai b\u00ean g\u00f2 m\u00e1\u2026 Ngo\u00e0i ra n\u00e1m c\u00f2n xu\u1ea5t hi\u1ec7n \u1edf nhi\u1ec1u v\u1ecb tr\u00ed kh\u00e1c tr\u00ean c\u01a1 th\u1ec3 \u2013 nh\u1eefng v\u00f9ng th\u01b0\u1eddng xuy\u00ean ti\u1ebfp x\u00fac v\u1edbi tia UV. K\u00edch th\u01b0\u1edbc c\u1ee7a n\u00e1m da kh\u00e1c nhau t\u00f9y theo t\u1eebng c\u01a1 \u0111\u1ecba xu\u1ea5t hi\u1ec7n. N\u00f3 c\u00f3 th\u1ec3 l\u00e0 m\u1ea3ng l\u1edbn ho\u1eb7c nh\u1eefng ch\u1ea5m nh\u1ecf li ti. N\u00e1m da c\u0169ng c\u00f3 th\u1ec3 lan r\u1ed9ng ra xung quanh n\u1ebfu b\u1ea1n kh\u00f4ng bi\u1ebft c\u00e1ch b\u1ea3o v\u1ec7 v\u00e0 ch\u0103m s\u00f3c da h\u1ee3p l\u00fd.<\/p>\n<p>V\u00e0 ai c\u0169ng c\u00f3 th\u1ec3 t\u00ecm hi\u1ec3u \u0111\u01b0\u1ee3c nguy\u00ean nh\u00e2n h\u00ecnh th\u00e0nh n\u00e1m xu\u1ea5t ph\u00e1t t\u1eeb 2 nguy\u00ean nh\u00e2n ch\u00ednh:<\/p>\n<ul>\n<li>M\u1ed9t l\u00e0 do c\u00e1c t\u00e1c nh\u00e2n b\u00ean ngo\u00e0i nh\u01b0 kh\u00f3i, b\u1ee5\u1ecb, tia UV ho\u1eb7c s\u1eed d\u1ee5ng m\u1ef9 ph\u1ea9m kh\u00f4ng \u0111\u00fang c\u00e1ch, m\u1ef9 ph\u1ea9m k\u00e9m ch\u1ea5t l\u01b0\u1ee3ng<\/li>\n<li>Hai l\u00e0 do t\u00e1c nh\u00e2n b\u00ean trong nh\u01b0 thay \u0111\u1ed5i n\u1ed9i ti\u1ebft t\u1ed1, ph\u1ea3n \u1ee9ng v\u1edbi thu\u1ed1c hay mang thai ho\u1eb7c ti\u1ec1n m\u00e3n kinh,,\u2026<\/li>\n<\/ul>\n<p>Tuy nhi\u00ean, trong b\u00e0i vi\u1ebft n\u00e0y, DLC VINA mu\u1ed1n chia s\u1ebb v\u1edbi c\u00e1c b\u1ea1n nguy\u00ean nh\u00e2n s\u00e2u xa h\u01a1n g\u00e2y ra t\u00ecnh tr\u1ea1ng n\u00e1m da l\u00e0 do ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3, \u0111i\u1ec3n h\u00ecnh l\u00e0 qu\u00e1 tr\u00ecnh k\u00edch ho\u1ea1t v\u00e0 t\u1ed5ng h\u1ee3p melanin- nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y h\u00ecnh th\u00e0nh n\u00e1m da<\/p>\n<h2>T\u1ed5ng quan v\u1ec1 qu\u00e1 tr\u00ecnh k\u00edch ho\u1ea1t v\u00e0 t\u1ed5ng h\u1ee3p Melanin- nguy\u00ean nh\u00e2n ch\u00ednh g\u00e2y ra n\u00e1m da<\/h2>\n<h3>1.\u00a0\u00a0 Qu\u00e1 tr\u00ecnh k\u00edch ho\u1ea1t Melanin<\/h3>\n<p><strong>Melanin l\u00e0 s\u1eafc t\u1ed1 quy\u1ebft \u0111\u1ecbnh m\u00e0u da c\u1ee7a m\u1ed7i ng\u01b0\u1eddi<\/strong>, \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb nh\u1eefng t\u1ebf b\u00e0o da g\u1ecdi l\u00e0\u00a0melanocytes (t\u00ea\u0301 ba\u0300o bi\u00ea\u0300u bi\u0300 ta\u0323o h\u0103\u0301c t\u00f4\u0301), v\u00e0 n\u1eb1m ph\u00e2n b\u1ed1 \u1edf l\u1edbp \u0111\u00e1y c\u1ee7a th\u01b0\u1ee3ng b\u00ec.\u00a0Melanocytes c\u00f3 ch\u1ee9a enzyme Tyrosinase.<\/p>\n<p>V\u1ed1n \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh t\u1eeb melanocytes, n\u00ean melanin n\u1ebfu mu\u1ed1n \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh th\u00ec c\u1ea7n ph\u1ea3i c\u00f3 s\u1ef1 t\u00e1c \u0111\u1ed9ng c\u1ee7a men Tyrosinase k\u1ebft h\u1ee3p v\u1edbi tia t\u1eed ngo\u1ea1i c\u00f3 trong \u00e1nh n\u1eafng m\u1eb7t tr\u1eddi. Ngo\u00e0i ra s\u1ef1 t\u1ea1o th\u00e0nh melanin c\u00f2n ch\u1ecbu \u1ea3nh h\u01b0\u1edfng b\u1edfi n\u1ed9i ti\u1ebft t\u1ed1 v\u00e0 th\u1ea7n kinh.<\/p>\n<h3>2.\u00a0\u00a0 Qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p Melanin<\/h3>\n<p>Sau khi Tyrosinase \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, giai \u0111o\u1ea1n t\u1ed5ng h\u1ee3p melanin \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong m\u1ed9t c\u01a1 quan c\u1ee7a t\u1ebf b\u00e0o s\u1eafc t\u1ed1 g\u1ecdi l\u00e0 melanosome. Giai \u0111o\u1ea1n t\u1ed5ng h\u1ee3p melanin bao g\u1ed3m 3 ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc:<\/p>\n<ul>\n<li>Ph\u1ea3n \u1ee9ng \u0111\u1ea7u ti\u00ean l\u00e0 enzyme Tysorinase chuy\u1ec3n m\u1ed9t acid amin l\u00e0 tysosine th\u00e0nh DOPA<\/li>\n<li>Ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc th\u1ee9 hai l\u00e0 chuy\u1ec3n DOPA th\u00e0nh Dopaquinone<\/li>\n<li>Ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc th\u1ee9 3 l\u00e0 chuy\u1ec3n Dopaquinone th\u00e0nh m\u1ed9t trong 2 d\u1ea1ng melanin t\u00f9y theo m\u00e0u da c\u1ee7a ch\u1ee7ng t\u1ed9c l\u00e0 Pheo-melanin hay EU-melanin.<\/li>\n<\/ul>\n<p>Sau khi th\u1ef1c hi\u1ec7n xong vi\u1ec7c t\u1ed5ng h\u1ee3p melanin trong c\u00e1c t\u00fai melanosome, t\u1ebf b\u00e0o Melanocyte chuy\u1ec3n giao c\u00e1c \u201cb\u01b0u ki\u1ec7n\u201d melanosome \u0111\u00e3 \u201c\u0111\u00f3ng g\u00f3i\u201d melanin cho t\u1ebf b\u00e0o keratinocyte \u0111\u01b0a l\u00ean l\u1edbp bi\u1ec3u b\u00ec c\u1ee7a da v\u00e0 k\u1ebft th\u00fac cu\u1ed9c h\u00e0nh tr\u00ecnh.<\/p>\n<h2>C\u00e1c ho\u1ea1t ch\u1ea5t h\u1ed7 tr\u1ee3 ng\u0103n ng\u1eeba n\u00e1m da<\/h2>\n<p>M\u1ed7i th\u00e0nh ph\u1ea7n l\u00e0m s\u00e1ng da t\u00f9y \u0111\u1eb7c t\u00ednh h\u00f3a sinh s\u1ebd tham gia v\u00e0o m\u1ed9t giai \u0111o\u1ea1n nh\u1ea5t \u0111\u1ecbnh c\u1ee7a qu\u00e1 tr\u00ecnh n\u00e0y. C\u00f3 th\u00e0nh ph\u1ea7n tham gia v\u00e0o giai \u0111o\u1ea1n \u0111\u1ea7u ch\u1eb7n s\u1ef1 k\u00edch ho\u1ea1t tysosinase, c\u00f3 th\u00e0nh ph\u1ea7n \u1ee9c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p tysosinase th\u00e0nh melanin. C\u00f9ng DLC VINA\u00a0 t\u00ecm hi\u1ec3u m\u1ed9t s\u1ed1 ho\u1ea1t ch\u1ea5t l\u00e0m s\u00e1ng da hi\u00eauj q\u1ee7a v\u00e0 tham gia v\u00e0o qu\u00e1 tr\u00ecnh ng\u0103n ch\u1eb7n h\u00ecnh th\u00e0nh n\u00e1m tr\u00ean da<\/p>\n<h3>1. Melazero<\/h3>\n<p>Melazero l\u00e0 m\u1ed9t ch\u1ea5t l\u00e0m tr\u1eafng th\u1ebf h\u1ec7 th\u1ee9 3 c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ef1c v\u1eadt.\u00a0<strong>Melazero<\/strong>\u00a0l\u00e0 gi\u1ea3i ph\u00e1p ho\u00e0n ch\u1ec9nh gi\u00fap x\u00f3a b\u1ecf v\u00e0 \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh melanin tr\u00ean da m\u00e0 kh\u00f4ng g\u00e2y t\u00edch t\u1ee5 ch\u1ea5t \u0111\u1ed9c h\u1ea1i cho t\u1ebf b\u00e0o hay k\u00edch \u1ee9ng da. Nh\u1edd c\u00f3 c\u01a1 ch\u1ebf k\u00e9p: \u1ee8c ch\u1ebf s\u1ef1 t\u1ed5ng h\u1ee3p Tyrosinase ng\u0103n ch\u1eb7n qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t melanin v\u00e0 s\u1eed d\u1ee5ng Autophagy- m\u1ed9t c\u01a1 ch\u1ebf t\u1eebng \u0111o\u1ea1t gi\u1ea3i Nobel \u0111\u1ec3 x\u00f3a b\u1ecf c\u00e1c h\u1eafc t\u1ed1 hi\u1ec7n c\u00f3. \u0110i\u1ec1u n\u00e0y, \u0111\u00e3 gi\u00fap cho Melazero l\u00e0 m\u1ed9t ch\u1ea5t l\u00e0m tr\u1eafng hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n<\/p>\n<h3>2. Vitamin B3<\/h3>\n<p>Vitamin B3 ( Niacinamide) l\u00e0 h\u1ee3p ch\u1ea5t c\u1ee7a lipid, n\u00f3 g\u00f3p ph\u1ea7n c\u1ea5u th\u00e0nh ch\u1ee9c n\u0103ng v\u00e0 c\u1ea5u tr\u00fac c\u1ee7a c\u00e1c h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7 da. C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Vitamin B3 l\u00e0 khi Tyrosinase \u0111\u01b0\u1ee3c k\u00edch ho\u1ea1t, qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p melanin \u0111\u00e3 di\u1ec5n ra th\u00ec ho\u1ea1t ch\u1ea5t Vitamin B3 n\u00e0y s\u1ebd ng\u0103n ch\u1eb7n kh\u00f4ng cho c\u00e1c melanin \u0111\u01b0\u1ee3c \u201c v\u1eadn chuy\u1ec3n\u201d l\u00ean l\u1edbp bi\u1ec3u b\u00ec c\u1ee7a da<\/p>\n<h3>3. Tranexamic Acid<\/h3>\n<p>\u0110\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u00e0 th\u00e0nh ph\u1ea7n x\u00f3a m\u1edd th\u00e2m n\u00e1m an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3, Tranexamic Acid n\u1ed5i l\u00ean nh\u01b0 m\u1ed9t hi\u1ec7n t\u01b0\u1ee3ng l\u1ea1 \u0111\u01b0\u1ee3c c\u00e1c t\u00edn \u0111\u1ed3 y\u00eau l\u00e0m \u0111\u1eb9p s\u0103n \u0111\u00f3n. G\u1ea7n 96% nh\u1eefng ng\u01b0\u1eddi tham gia nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng\u00a0<strong>axit tranexamic<\/strong>\u00a0\u0111\u00e3 cho th\u1ea5y kh\u1ea3 n\u0103ng th\u00e2m n\u00e1m c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 sau 12 tu\u1ea7n s\u1eed d\u1ee5ng khi k\u1ebft h\u1ee3p v\u1edbi kem ch\u1ed1ng n\u1eafng ph\u1ed5 r\u1ed9ng.<\/p>\n<p>C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ho\u1ea1t ch\u1ea5t n\u00e0y l\u00e0 TXA \u1ee9c ch\u1ebf chuy\u1ec3n plasminogen th\u00e0nh plasmin th\u00f4ng qua vi\u1ec7c g\u1eafn c\u1ea1nh tranh v\u1edbi lysin tr\u00ean plasminogen \u1edf t\u1ebf b\u00e0o gai. T\u1eeb \u0111\u00f3 l\u00e0m gi\u1ea3m gi\u1ea3i ph\u00f3ng arachidonic acid, gi\u1ea3m s\u1ea3n xu\u1ea5t prostaglandin, gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng tyrosinese v\u00e0 gi\u1ea3m sinh t\u1ed5ng h\u1ee3p melanin.<\/p>\n<h3>4. Kojic Acid<\/h3>\n<p>Kojic acid sinh ra t\u1eeb chi\u1ebft xu\u1ea5t c\u1ee7a n\u1ea5m v\u00e0 qu\u00e1 tr\u00ecnh l\u00ean men c\u1ee7a r\u01b0\u1ee3u g\u1ea1o, r\u01b0\u1ee3u sake,\u2026 \u00a0Axit Kojic ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n tyrosine h\u00ecnh th\u00e0nh, t\u1eeb \u0111\u00f3 ng\u0103n ch\u1eb7n s\u1ea3n xu\u1ea5t melanin. Gi\u1ea3m s\u1ea3n xu\u1ea5t melanin c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng l\u00e0m s\u00e1ng da.<\/p>\n<h3>5. Arbutin<\/h3>\n<p>L\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n ho\u1ea1t ch\u1ea5t c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ef1c v\u1eadt, Arbutin gi\u1ea3m m\u1ee9c \u0111\u1ed9 s\u1ea1m da khi ti\u1ebfp x\u00fac v\u1edbi tia c\u1ef1c t\u00edm, c\u00e1c \u0111\u1ed1m da s\u1ea1m m\u00e0u\u2026 b\u1eb1ng c\u00e1ch \u1ee9c ch\u1ebf c\u00e1c ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Tyrosinase ng\u0103n ng\u1eeba h\u00ecnh th\u00e0nh melanin g\u00e2y s\u1ea1m da, n\u00e1m,\u2026<\/p>\n","protected":false},"excerpt":{"rendered":"<p>N\u00e1m da l\u00e0 g\u00ec? N\u00e1m da l\u00e0 m\u1ed9t r\u1ed1i lo\u1ea1n s\u1eafc t\u1ed1 x\u1ea3y ra khi qu\u00e1 tr\u00ecnh r\u1ed1i lo\u1ea1n melanin t\u0103ng ti\u1ebft, l\u01b0\u1ee3ng melanin \u0111\u01b0\u1ee3c s\u1ea3n sinh nhi\u1ec1u v\u00e0 b\u1ecb \u0111\u1ea9y s\u00e2u v\u00e0o b\u00ean trong l\u1edbp th\u01b0\u1ee3ng b\u00ec. Hi\u1ec3u m\u1ed9t c\u00e1ch \u0111\u01a1n gi\u1ea3n h\u01a1n th\u00ec n\u00e1m da l\u00e0 t\u00ecnh tr\u1ea1ng da xu\u1ea5t hi\u1ec7n nh\u1eefng \u0111\u00e1m [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1588,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-1587","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc-su-kien"],"_links":{"self":[{"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/posts\/1587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hencosvn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1587"}],"version-history":[{"count":1,"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/posts\/1587\/revisions"}],"predecessor-version":[{"id":1589,"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/posts\/1587\/revisions\/1589"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hencosvn.com\/index.php?rest_route=\/wp\/v2\/media\/1588"}],"wp:attachment":[{"href":"https:\/\/hencosvn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1587"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hencosvn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1587"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hencosvn.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}